If you've ever fooled around in the world of medicine or business or, for that matter, Wall Street (And don't let the term, fool around, distort what we're saying here, though we know it will be difficult.), don't miss this read.
Now here's a little teaser. You need to know this is scientific prose, we use the word prose advisedly, so the water can be a little cold and the current a bit turbulent.
But as the saying goes frown a lot and bear your way through it.
"Is it unavoidable that most research findings are false, or can we improve the situation? A major problem is that it is impossible to know with 100% certainty what the truth is in any research question. In this regard, the pure “gold” standard is unattainable. However, there are several approaches to improve the post-study probability."
http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.0020124
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